Hotkeys not working after new PC update

Just downloaded the update that changed the layout, etc, and suddenly the hotkeys do not work. I tried various games, and the cheats work, but I have to manually click on them. My hotkeys work on my computer, the app just doesn’t seem to recognize them. I tried to remake the hotkey the executable button, but the app did not even recognize that I was pressing anything. Should I reinstall, or do I suddenly have to go pro to use the hotkeys or something?

ive had the same issue sometimes with some games, not sure what causes it.