First, let me say, I love this app. It has gotten me through some tough situations. 
However, after playing for a while with wemod enabled, my sound starts to get choppy and crunchy. I can switch output devices and switch back, and it will clear up for a while, but then it comes back. If I let it carry on, the sound stops working altogether. I know this isn’t game-related as it happens with every game and it only happens with wemod enabled.
Windows 10 Home
32GB RAM
X399 AORUS Gaming 7 Mobo
AMD Ryzen Threadripper 1950X 3400Mhz, 16-Core
Focusrite Scarlett 2i2 USB Audio
Hello and welcome back to the community. 
Sorry to hear that you are having a sound issue.
Game
Are there any specific games that are having this issue?
As far as I am aware throughout my years here, I have only ever heard of sound issues in one game when using WeMod, and that’s the very recently released game of Starfield. The fix for the sound issue in Starfield is to launch the game before launching WeMod. Try that.
Starfield does not have any sound when using WeMod - Fix
Hardware
I do not own any audio devices from this brand. However, I am aware that this brand is actually well-known for being related to choppy, broken, or laggy audio in their second and third generation devices. External examples below.
Scarlett 2i2 (2nd Gen) Choppy Audio
Focusrite Scarlett Solo 3rd Gen will be fine then gets a stutter and a delay
Scarlett Stutters then audio delay issue?
Those links contain a few suggestions from others who use those devices. The company’s own website also offers some advice to try: https://support.focusrite.com/hc/en-gb/articles/207355205-Optimising-Windows-10-for-Audio.
My guess, as someone unable to test this theory, is that your audio goes weird due to buffer size issues when a (muted by default) advert shows up in the WeMod software, to help free users to cover the costs of WeMod’s expensive development.
Another thing to consider is that USB devices in general, not limited to just audio devices nor to any particular brand, are known for having latency issues compared to native or built-in hardware. Check that you aren’t using a low-powered USB port - USB 2.0 will of course be slower at transferring data from the computer to the device (and vice versa) than USB 3.0, for example. Consult your machine’s technical handbook online if unsure which speed each of your USB ports are.
Take a look at some of the links, hopefully there’s something helpful there.
Have a great weekend in the meantime!
Hello Ravenfyre, thank you for your response.
Game
It happens with all games, both with low-end games like Broforce, and high-end games such as Jedi Survivor and Cyberpunk 2077. If I don’t use wemod, the sound issues never happen.
Hardware
The Scarlett 2i2 that I use is first-gen and is audio gear that is used for recording and music production. It requires USB 3.0, so it’s definitely connected correctly. I use it with high-end recording software like Ableton, and it never gives me any issues. Also, I’m familiar with what latency is and this issue is not latency. The best I can describe it is like sound being played through sandpaper. I will record a sample when it happens again.
To test your theory, I went Pro, and although it doesn’t happen as often now, it still happens. But if I turn off wemod, it doesn’t happen at all.