WeMod will not install

For me, the launch and (re)install problems started after the last Cumulative Update for Windows 10 (December 10, 2024—KB5048652).
I’ve recently purchased two programs which installed in the %USERPROFILE%\AppData\Local\ and %USERPROFILE%\AppData\Roaming\ directories. Both of them failed to launch with the same eventlog error as with WeMod, i.e. with the exception code 0xc06d007e in KERNELBASE.dll.
So my gaze is upon Microsoft with its latest update. I have a hunch it renders programs installed under %USERPROFILE%\AppData\ ‘incompatible’.
FWIW:
I did manage to (re)install WeMod by running the WeMod-Setup.exe in Windows 8 compatibility mode. WeMod will launch after install, but it’s a one-off. Once you close WeMod (taskbar), it will not launch again (re-install needed).
See post: We mod Problem - #5 by Pattoman